Welcome to the Punihaole Lab at the University of Vermont!

Our lab’s research interests lie at the intersection of analytical and physical chemistry, biophysics, as well as materials science. We are working towards changing the paradigm of biological imaging . To do this, we seek to “bring spectroscopy back to microscopy” by harnessing the chemical information encoded in Raman spectra to directly visualize the structural dynamics and interactions of biological macromolecules in their native cellular environment. We are using our novel Raman chemical imaging technology to study how cells regulate protein folding, development insights into how amyloid fibril aggregates influence the pathophysiology of Alzheimer’s Disease, as well as determine structure-activity relationships in nanoparticle gene and drug delivery vehicles to improve their efficacy in treating diseases.

We are currently seeking motivated graduate students with interests in chemistry, biophysics, and/or materials science to join our lab. Exceptional undergraduate students majoring in biochemistry or related fields are welcome to apply. Prospective students can find out more information about joining by filling out an application form. Prospective graduate student applicants should apply to the Chemistry or the Materials Science graduate programs. For questions, please email Professor David Punihaole (David.Punihaole@uvm.edu).